Convergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells

In the search for new fluorescent triphenylamine (TP) derivatives, we studied influence of position and substitution diverse heterocyclic substituents. A library 10 triphenylamines bearing either oxazoles or thiazoles pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C−H activation reaction between pyridine-oxazoles pyridine-thiazoles di-iodo triphenylamine. We showed that nature pattern 5-membered- (oxazole, thiazole) 6-membered heterocycle (pyridine) strong their fluorescence properties localization in living cells as they stain nucleus mitochondria.